Large quantities of SO2 and NOx in coke oven flue gas are the main pollutants forming the acid rain and haze. In order to implement the basic national policy of environmental protection production, it has become an urgent task for major enterprises to desulfurize, denitrify and dedust from the coke oven flue gas. The application of the process of SDS dry desulfurization and SCR denitrification and dedusting at medium and low temperature in practical engineering was investigated, the process had high efficiency, few byproducts and strong impact resistance. It was a kind of advanced coke oven flue gas purification technologies in the world. SDS+SCR process was used to treat the flue gas of No.8 coke oven in the coking plant of Angang Steel Company Limited. The results showed that when the average concentrations of SO2, NOx and dust in the coke oven flue gas at the entrance of the equipment were 83.84, 439.67 and 18.43 mg/m3, respectively, the concentrations of the three pollutants in the outlet flue gas were lower than 30, 150 and 5 mg/m3， meeting the emission requirements of GB 16171—2012. The study can provide a reference scheme and experience for the pollution control of the coking industry.