The main content of intelligent manufacturing and intelligent design on iron and steel manufacturing process are analyzed. The intelligent manufacturing of iron and steel manufacturing process includes the intelligent process design, the intelligent process production and operation, the intelligent process management, the intelligent process supply chain, the intelligent process service system. The intelligent design of iron and steel manufacturing process includes the basic scientific research, adopting CAE threedimensional simulation design analysis and computing technology, the technical science research, adopting mechanical engineering threedimensional simulation design technique, the engineering science research, adopting digitization threedimensional simulation plant layout technique. Realizing the intelligent manufacturing of iron and steel manufacturing process, the intelligent design is not only a key link of intelligent manufacturing, but also plays a leading role. Without advanced intelligent design, it is difficult to have advanced intelligent manufacturing, and it is necessary to attach great importance to the intelligent design of iron and steel manufacturing process. The advanced degree of intelligent design determines the advanced level and future of intelligent manufacturing.