The anti-oxidation mechanism and corrosion protection principle at high temperature were studied in the laboratory. The coating sample and the normal hot-transporting slab were fed into the reheating furnace, to systematically analyze the temperature change and surface change of the slabs within the process from continuous casting to reheating furnace, especially to investigate its oxidation state. The anti-oxidation formula of slab in Laigang and the implementation method of spraying were studied to reduce the oxiding loss of slabs in the reheating furnace and enhance the yield of slabs. At last, the formula of anti-oxidation coating was confirmed and the corresponding test was carried out. The result shows that the coating slab not only has no influence on the rolling schedule, but also its surface oxidation is reduced and the surface quality of steel products is improved.