The production practice of X65MS pipeline steel with HIC resistance property on 2 250 mm hot rolling pro- duction line was briefly introduced in Shougang Qiangang in present work. The composition and technology charac- teristics of X65MS were introduced. The mechanical properties， microstructures and HIC resistance property were tested. The investigation result shows that the development of anti-HIC pipeline steel X65MS was successfully a- chieved using TMCP technology on 2 250 mm hot rolling production line with rational composition design and clean- ness control. The products showed excellent mechanical and HIC resistance properties.