Through systematical summaries on the work roll failures occurred in 2 250 mm hot strip mill of Shougang Qian'an Iron and Steel Company， the roll material defects generated during the manufacturing processes and the contact pressure concentration between rolls are the main reasons. According to the analytical results， preventing measures are given and applied. Higher requirements on roll material was put up forward to avoid the manufacture defects such as excessive retained austenite in work layer， bad spheroidization of graphite in roll core， Cr permeating in binder layer and the core and so on. Roll spalling and breaking failures resulted by roll material defects were elimi- nated thoroughly. For preventing the roll failures from incorrect using， the works of defect detection and inspection were enhanced to avoid using unqualified roll on mill. Roll failure behaviors were avoided effectively after the using management of rolls was strengthened. Roll spalling problems resulted by roll edge contact stress concentration were solved through applying the roll contour technology.